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Hypothyroidism and Diet Thyroid hormones affect glucose metabolism in several organs, including the liver, pancreas (which influences -cells), the gastrointestinal tract, adipose tissue, skeletal muscles, and the central nervous system [85]

These abnormalities lead to neural dysfunction, synaptic loss, and ultimately, neuronal death

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2 Biosynthesis of melanin and its regulation 2.1 Melanin synthesis pathway The specific process of melanin synthesis begins with the conversion of tyrosine into L-Dopa catalysed by tyrosinase, the central glycoprotease in the melanosome region and the only rate-limiting enzyme in this process (Kim et al., 2023)